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Ets 家族的转录因子在造血细胞的生存、生长和分化方面起着重要的作用。而 PU.1是 Ets 家族中最重要的转录因子。PU.1蛋白的 C 末端结合区域与 Ets-1极其相似。与其他 Ets 家族转录因子一样,GGAA 是 PU.1的结合点。在体外,GAGGAA 是 PU.1的理想结合点。PU.1主要表达于造血细胞,包括 CD34细胞、巨噬细胞、B 淋巴细胞、中性粒细胞、肥大细胞和原始红细胞等。最近的研究表明,PU.1与中性粒细胞、巨噬细胞、巨核细胞、红细胞、成骨细胞、嗜酸细胞、
The Ets family of transcription factors play an important role in the survival, growth and differentiation of hematopoietic cells. While PU.1 is the most important transcription factor in the Ets family. The C-terminal binding region of PU.1 protein is very similar to Ets-1. Like other Ets family transcription factors, GGAA is the binding site for PU.1. In vitro, GAGGAA is an ideal binding site for PU.1. PU.1 is mainly expressed in hematopoietic cells, including CD34 cells, macrophages, B lymphocytes, neutrophils, mast cells and primitive erythrocytes. Recent studies have shown that PU.1 and neutrophils, macrophages, megakaryocytes, erythrocytes, osteoblasts, eosinophils,