目的　观察国产降纤酶对急性脑梗死的溶栓治疗效果。方法　随机选择临床确诊的急性脑梗死患者 ,发病在 3～ 1 2 h以内者 5 6例 ,给予降纤酶静脉溶栓治疗 ,采用加拿大人神经病学评分在 2 4 h内明显增加者 37例 ,占 6 6 % ;4 8h内明显增加者 4 2例 ,占 75 % ;72 h内明显增加者 5 4例 ,占 96 %。 2例病人计分无明显变化 ,占 4 %。结论　国产降纤酶对发病 1 2 h以内的急性脑梗死病人临床溶栓效果良好。 Objective To observe the effect of domestic defibrase on thrombolytic therapy in acute cerebral infarction. Methods A total of 56 patients with acute cerebral infarction who were clinically diagnosed were enrolled in this study. Fifty-six patients were included within 3 to 12 hours. Thrombolytic therapy with defibrase was given intravenously. Thirty-seven patients with Canadian neurological score significantly increased within 24 hours. Accounting for 66%; 48 cases significantly increased in 42 cases, accounting for 75%; 72 h obvious increase 54 cases, accounting for 96%. Two patients did not score significant changes, accounting for 4%. Conclusion Domestic defibrase has a good effect in clinical thrombolytic therapy in patients with acute cerebral infarction within 1 2 h.