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高分辨FISH技术已成为人类基因定位和临床遗传学中的重要手段,已经发展了一系列利用FISH对大小在1～1000kb的探针在R-显带的染色体上直接进行定位的技术。作者介绍了一种利用色霉素A_3和偏端霉素染色进行R-显带的方法,使得利用
High-resolution FISH has become an important tool in human gene mapping and clinical genetics. A series of techniques have been developed for direct mapping of R-banding chromosomes by FISH on probes ranging in size from 1 to 1000 kb. The authors describe a method of R-banding using chromomycin A_3 and doxorubicin staining, making use of