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Interferon (IFN)-γ,a potent proinflammatory cytokine produced by multiple types of cells (e.g.,activated T,NKand NKT cells),plays important and complex roles in both innate and adaptive immune responses.There may be acorrelation between the IFN-γ level and GVHD severity in patients receiving allogeneic hematopoietic celltransplantation.However,such a correlation may just reflect the presence of large numbers of activated T cells,and does not necessarily imply a harmful role of IFN-γ in the pathogenesis of GVHD.There has been increasingexperimental evidence that IFN-γ is not required and may even inhibit GVHD.Paradoxically,IFN-γ facilitatesgraft-versus-leukemic (GVL) effects.Thus,IFN-γ blockade is likely deleterious in patients after allogeneichematopoietic cell transplantation,and not beneficial as previously suggested.Cellular & Molecular Immunology.2005;2(5):323-329.
Interferon (IFN) -γ, a potent proinflammatory cytokine produced by multiple types of cells (eg, activated T, NK and NKT cells), plays important and complex roles in both innate and adaptive immune responses. Here may be acorrelation between the IFN-γ level and GVHD severity in patients receiving allogeneic hematopoietic cell transplantation. However, such a correlation may just reflect the presence of large numbers of activated T cells, and does not necessarily imply a harmful role of IFN-γ in the pathogenesis of GVHD. There has been increasingexperimental evidence that IFN-γ is not required and may even inhibit GVHD.Paradoxically, IFN-γ facilitatesgraft-versus-leukemic (GVL) effects.Thus, IFN-γ blockade is likely to deleterious in patients after allogeneic hematopoietic cell transplantation, and not beneficial as previously suggested. Cellular & Molecular Immunology. 2005; 2 (5): 323-329.