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目的探讨降钙素原(PCT)定量检测判断脓毒症患儿革兰阴性菌(GN)感染及革兰阳性菌(GP)感染的临床价值。方法回顾性分析2011年12月-2012年4月湖南省儿童医院所有诊断为脓毒症的住院患儿的病历资料,比较GN感染患儿及GP感染患儿PCT水平,根据ROC曲线判断PCT的诊断性能。结果共83例脓毒症患儿纳入研究,GN感染者住院时间较GP感染者短、PCT水平较GP感染者高,PCT区分GN及GP的敏感性、特异性、准确度分别为78.6%、81.5%、79.5%,ROC曲线下面积为0.801。结论 PCT对区分脓毒症患儿革兰阴性菌及革兰阳性菌感染具有一定的临床价值,可辅助指导临床早期合理应用抗生素。
Objective To investigate the clinical value of procalcitonin (PCT) quantitative detection in detecting Gram-negative bacteria (GN) infection and gram-positive bacteria (GP) infection in septic children. Methods The clinical data of all hospitalized children diagnosed as sepsis from Hunan Provincial Children’s Hospital from December 2011 to April 2012 were retrospectively analyzed. The PCT levels in children with GN infection and children with GP infection were compared. The PCT of PCT Diagnostic performance. Results A total of 83 children with sepsis were enrolled in this study. The length of stay in hospitalized patients with GN was shorter than those with GP, the PCT levels were higher than those with GP. The sensitivity, specificity and accuracy of GN and GP were 78.6% 81.5%, 79.5%, the area under the ROC curve is 0.801. Conclusion PCT has certain clinical value in differentiating Gram-negative bacteria and Gram-positive bacterial infections in children with sepsis and can guide the rational use of antibiotics early in clinical practice.