论文部分内容阅读
目的探讨儿童急性白血病合并医院感染的易感因素。方法回顾性分析本院血液科2001年1月至2007年12月收治的48例急性白血病患儿发生医院感染的易感因素。结果医院感染与患儿的周围血白细胞计数(尤其是中性粒细胞计数)、化疗阶段和强度及住院时间等有明显关系。感染的病原菌主要是革兰氏阴性菌。结论化疗后较长时间的中性粒细胞缺乏应为儿童急性白血病合并医院感染的最直接和最关键的易感因素。应用粒细胞刺激因子(G-CSF)、静脉用丙种球蛋白及加强支持对症治疗等能减少医院感染的发生。
Objective To investigate the susceptibility factors of acute leukemia in children with nosocomial infection. Methods Retrospectively analyzed the susceptibility factors of nosocomial infection in 48 children with acute leukemia admitted from January 2001 to December 2007 in our department of hematology. Results There was a significant relationship between nosocomial infection and peripheral white blood cell count (especially neutrophil count), stage and intensity of chemotherapy and hospital stay. Infected pathogens are mainly Gram-negative bacteria. Conclusion Long-term neutropenia after chemotherapy should be the most direct and most critical predisposing factor for childhood acute leukemia complicated with nosocomial infections. The use of granulocyte-stimulating factor (G-CSF), intravenous gamma globulin and supportive symptomatic treatment can reduce the incidence of nosocomial infections.