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本文对吐鲁大地区２个水氟含量不同〔其含量分别为０．９１ｍｇ／Ｌ（Ａ村）和０．５８ｍｇ／Ｌ（Ｂ村）〕的居民村维吾尔族居民饮水量、摄氟量、尿氟和血清Ｆｅ、ｚｎ、Ｃａ和Ｍｇ含量以及氟斑牙患病率进行了分析。结果显示，居民夏季饮水量明显升高（５～８Ｌ／ｄ），饮水摄氟量增多。尿氟含量增加，并出现氟中毒患者。氟斑牙患病率Ａ村为６５．５７％；Ｂ村为４８．９３％。通过对两村居民血清Ｆｅ、Ｚｎ、Ｃａ和Ｍｇ含量分析，发现血清Ｚｎ和Ｍｇ含量，两村居民无明显差异（Ｐ＞０．０５），说明短期（夏季）过量摄氟对Ｚｎ和Ｍｇ代谢的影响不大，但血清Ｆｅ和Ｃａ差别显著，Ａ村居民血清Ｆｅ含量明显升高，血清Ｃａ含量明显降低。表明氟对血清Ｆｅ和Ｃａ的代谢有明显影响。由此可见，氟对机体的损伤不仅表现为直接损伤，还可通过影响体内无机元素的代谢造成损伤。
In this paper, two groups of Uygur residents in the Tulu area, which have different fluoride contents (0.91 mg / L (A) and 0.58 mg / L Urinary fluoride and serum Fe, Zn, Ca and Mg levels and the prevalence of dental fluorosis were analyzed. The results showed that residents in summer increased significantly (5 ~ 8L / d), fluoride intake increased. Urine fluoride increased, and fluorosis patients. The prevalence of dental fluorosis A village is 65.57%; B village is 48.93%. By analyzing the contents of Fe, Zn, Ca and Mg in serum of two villages, we found that the content of serum Zn and Mg in two villages showed no significant difference (P> 0.05), indicating that short-term (summer) , But the difference of serum Fe and Ca was significant. The content of serum Fe in village A was obviously increased and the content of serum Ca was obviously decreased. This shows that fluoride has a significant effect on the metabolism of serum Fe and Ca. Thus, fluoride damage to the body is not only manifested as direct damage, but also by affecting the metabolism of inorganic elements in the body damage.