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本文对自发性高血压大鼠(SHR)和Wistar大鼠的血压,尿量,尿钠、钾,尿中排出6-keto-PGF_(1α)、TXB_2进行了观察研究。结果表明8～9周龄(2.92±1.08pg vs 2.05±0.2pg,P<0.01)。反映出PGI_2合成的增高可能对早期高血压具有防御代偿作用。在15～16周龄的SHR,随周龄、血压的增长,尿6-keto-PGF_(1α),TXB_2排出较8～9周龄组显著增高(P<0.01)。显示TXA_3合成占优势,PGI_2防御代偿能力减弱,提示T/P比值变化对血压调节作用远较PGI_2、TXA_2单纯变化更为重要。
In this paper, 6-keto-PGF_ (1α) and TXB_2 in blood pressure, urine output, urine sodium, potassium and urine in spontaneously hypertensive rats (SHR) and Wistar rats were observed and studied. The results showed 8 to 9 weeks of age (2.92 ± 1.08 pg vs 2.05 ± 0.2 pg, P <0.01). This shows that the increase of PGI-2 synthesis may have defensive compensation for early hypertension. With the increase of age and blood pressure, the urinary 6-keto-PGF_ (1α) and TXB_2 excretion in SHR of 15-16 weeks was significantly higher than that of 8-9 weeks old (P <0.01). It shows that TXA_3 synthesis predominates and PGI_2 defense compensatory ability is weakened, suggesting that the T / P ratio change is more important than BPI_2 and TXA_2 in the regulation of blood pressure.