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目的观察成人轻型β-地中海贫血筛查中可溶性转铁蛋白受体(Soluble transferrin receptor,s Tf R)联合红细胞参数检查的灵敏性与特异性。方法选取成人轻型β-地中海贫血患者、成人缺铁性贫血(IDA)患者及健康体检者各30例分别为观察组、IDA组、对照组,比较三组患者可溶性转铁蛋白受体、红细胞参数检查结果差异及各指标的敏感性和特异性。结果观察组与IDA组s Tf R均高于对照组,Hb、MCV、MCH、RDW均低于对照组,观察组s Tf R、RBC、Hb均高于IDA组,MCH低于IDA组,差异均有统计学意义(P<0.05),β-地中海贫血与IDA鉴别诊断中s Tf R、GKI、SLI、EFI、RI指数敏感性较高,EFI、GKI、RDWI指数及s Tf R的特异性较高。结论采用可溶性转铁蛋白受体联合红细胞参数筛查成人轻型β-地中海贫血并与缺铁性贫血进行鉴别诊断敏感性与特异性显著,可作为地中海贫血高发区的一种简单、方便、快捷的初筛手段,具有重要的实用价值。
Objective To observe the sensitivity and specificity of Soluble transferrin receptor (s Tf R) combined with erythrocyte parameters in screening of adult patients with β-thalassemia. Methods 30 adult patients with mild β-thalassemia were enrolled in this study. All 30 adult patients with IDA and 30 healthy controls were divided into observation group, IDA group and control group. The levels of soluble transferrin receptor, erythrocyte parameters Check the differences in the results and the sensitivity and specificity of the indicators. Results The values of s Tf R in observation group and IDA group were higher than those in control group. The levels of Hb, MCV, MCH and RDW in observation group and IDA group were lower than those in control group. The levels of s Tf R, RBC and Hb in observation group were higher than IDA group, (P <0.05). The specificity of s Tf R, GKI, SLI, EFI and RI indexes in the differential diagnosis of β-thalassemia and IDA was higher than those of IDA, but the specificity of EFI, GKI, RDWI index and s Tf R Higher. Conclusion The sensitivity and specificity of soluble transferrin receptor combined with erythrocyte parameters in the screening of adult patients with β-thalassemia and differential diagnosis of iron deficiency anemia can be used as a simple, convenient and rapid method for the diagnosis of thalassemia major Preliminary screening means, has important practical value.