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青光安颗粒剂为治疗青光眼手术后患者的药物,作者对其进行了急、慢性毒性试验。小白鼠的急性毒性试验表明,在给药量相当于成人临床用量291.8倍时,40只动物无一只死亡,观察期间亦无异常发现,该药对小鼠经口服的最大耐受量(MTD)大于75g/kg体重。大白鼠的慢性毒性试验表明,给动物连续灌药90天及停药后继续饲养15天,与对照组比较,其一般状况、病理组织学检查无显著性差异;血液学、血液生化学和动物的脏器系数在个别指标上虽有差异,但亦均在正常值范围内。
Qingguang’an granules are drugs used to treat patients after glaucoma surgery. The authors conducted acute and chronic toxicity tests. The acute toxicity test in mice showed that when the dose was equivalent to 291.8 times the clinical dose in adults, none of the 40 animals died and no abnormalities were observed during the observation period. The maximum tolerated dose of the drug to mice was oral. (MTD) greater than 75 g/kg body weight. Chronic toxicity tests in rats showed that animals were continuously dosed for 90 days and continued for 15 days after discontinuation. Compared with the control group, there was no significant difference in the general condition and histopathological examination; hematology, blood biochemistry and animal Although there are differences in the individual organ indicators, they are all within the normal range.