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随着对糖尿病研究的深入,目前对口服降糖药的要求已不局限于降糖,还要求有诸如调脂、对抗高凝状态等降糖以外的作用,双胍类药物正适合了这种要求。但长期以来有一种观点认为双胍类药物易致乳酸酸中毒,特别是在欧美,双胍类药物曾一度被禁用。为了详细了解双胍类药物(主要是二甲双胍)和乳酸酸中毒的关系,我们摘译了《Cochrane图书馆》这篇对从1959年开始有关于二甲双胍的所有研究进行的系统评价,以供临床医生参考。
With the deepening of the research on diabetes, the current demand for oral hypoglycemic agents is not limited to hypoglycemic, but also requires that other than hypoglycemic effect such as lipid-lowering, hypercoagulable state, the biguanide drugs are suitable for this requirement . But for a long time there is a view that biguanides are prone to lactic acidosis, especially in Europe and the United States, biguanides once disabled. In order to learn more about the relationship between biguanides (mainly metformin) and lactic acidosis, we have translated the Cochrane Library’s systematic review of all studies on metformin since 1959 for reference by clinicians .