论文部分内容阅读
目的探讨抗精子抗体(AsAb)在输精管结扎术后患者附睾液中的表达及其对生育力的影响。方法对2011年1月至2014年9月住院行输精管复通术的132例患者(A组)进行附睾液的AsAb检测,与同期132例育龄男性(B组)的精浆AsAb表达情况进行对比,随访1年,观察两组对象配偶的妊娠情况。结果 A组患者附睾液AsAb的总阳性率为9.10%(12/132),其中IgG为1.52%(2/132)、IgM为0.76%(1/132)、IgA为6.82%(9/132);B组的精浆AsAb总阳性率为8.33%(11/132),其中IgG为2.27%(3/132)、IgM为0.76%(1/132)、IgA为5.30%(7/132),两组间比较差异无统计学意义(P>0.05)。随访1年后,A组患者配偶的妊娠率为23.48%(31/132),略比B组34.85%(46/132)低,两者间比较差异有统计学意义(P<0.05)。结论输精管结扎术后附睾液中AsAb的表达程度与正常育龄男性精浆AsAb表达相当,但其复通后配偶的妊娠率要略比正常育龄期男性配偶的妊娠率低,AsAb可能对输精管复通后男性的生育力有一定影响。
Objective To investigate the expression of antisperm antibody (AsAb) in epididymal fluid of patients after vasectomy and its effect on fertility. Methods 132 AsAbs in epididymal fluid of 132 patients (Group A) admitted to hospital from January 2011 to September 2014 were compared with that of seminal plasma AsAb of 132 male of childbearing age (Group B) during the same period , Followed up for 1 year, observing the pregnancy status of the spouses in the two groups. Results The positive rate of AsAb in epididymis was 9.10% (12/132) in group A, including 1.52% (2/132) in IgG, 0.76% (1/132) in IgM and 6.82% (9/132) in IgA . The positive rate of AsAb in seminal plasma of group B was 8.33% (11/132), including 2.27% (3/132) in IgG, 0.76% (1/132) in IgM, 5.30% (7/132) in IgA, There was no significant difference between the two groups (P> 0.05). After one year of follow-up, the pregnancy rate of spouses in group A was 23.48% (31/132), which was slightly lower than 34.85% (46/132) in group B, with significant difference between the two groups (P <0.05). Conclusions The expression of AsAb in epididymal fluid after vasectomy is similar to that of normal seminal plasma in male Sprague-Dawley patients. However, the pregnancy rate of spouses after recanalization is slightly lower than that of male spouses in normal reproductive age. Male fertility has a certain impact.