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近年来,扑热息痛(AAP)中毒巳经引起了普遍的关注,大量资料证实,超剂量AAP可导致实验动物和人的严重肝坏死。我们从以下方面研究了甘草流浸膏对小鼠AAP肝毒性的保护作用。 对AAP中毒小鼠致死率的影响取18～24g小鼠30只,分成3组,两组分别ih1:3或1:4甘草流浸膏液0.2m1/10g(相当生药6.6和5g/kg),对照组给等容量生理盐水。第1天上午、下午和次日上午各给药1次,末次给药后1/2h各鼠均ip AAP 500mg/kg 观察24h的
In recent years, paracetamol (AAP) poisoning has aroused widespread concern, a large number of data confirm that overdose of AAP can lead to severe liver necrosis in laboratory animals and humans. We studied from the following aspects of licorice extract on mice AAP hepatotoxicity. Effect on lethality of AAP poisoning mice Thirty mice (18-24g) were divided into 3 groups: 0.2ml / 10g of ih1: 3 or 1: 4 licorice fluid extract (equivalent to 6.6 and 5g / kg of crude drug) , The control group to the same volume of saline. On the first day of the morning, afternoon and the next morning each administration 1, the last administration 1 / 2h after each mouse ip AAP 500mg / kg observed 24h