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目的 :探讨经皮冠状动脉介入治疗 (PCI)前后血浆白细胞介素 8(IL 8)的变化与早期并发症的关系。方法 :观察 12 1例冠心病患者PCI中和PCI后 30d内并发症 ,用ELISA法测定血浆IL 8和血清C 反应蛋白(CRP) ,流式细胞仪测定中性粒细胞表面 β2 黏合素Mac 1(CD11b/CD18)受体表达。结果 :12 1例中 16例出现早期并发症。16例早期并发症患者PCI前、后血浆IL 8、CRP、CD11b/CD18差值水平明显高于无早期并发症患者(均P <0 .0 5 )。随着IL 8、CRP、CD11b/CD18三分层由低到高 ,早期并发症明显增高 (均P <0 .0 5 )。经过多变量Logistic回归分析 ,PCI前IL 8、糖尿病对早期并发症具有独立预测价值。PCI后早期并发症组血浆IL 8差值与CD11b/CD18差值之间呈明显正相关 (r =0 .776 ,P <0 .0 1)。结论 :PCI后早期并发症的发生与PCI前存在的炎性反应程度有关。血浆IL 8水平正常者对PCI后早期并发症具有独立的阴性预测价值。
Objective: To investigate the relationship between the changes of plasma interleukin 8 (IL 8) and the early complications before and after percutaneous coronary intervention (PCI). Methods: The complications of PCI and PCI within 30 days after PCI were observed in 12 1 patients with coronary heart disease. The levels of IL-8 and CRP were measured by ELISA. The expression of β2-bin Mac 1 on neutrophils was detected by flow cytometry (CD11b / CD18) receptor expression. Results: Early complications occurred in 16 of 12 cases. The differences of plasma IL-8, CRP and CD11b / CD18 levels in 16 patients with early complications were significantly higher than those without early complications (all P <0.05). With the three layers of IL8, CRP, CD11b / CD18 from low to high, the early complications were significantly increased (all P <0.05). After multivariate Logistic regression analysis, pre-PCI IL 8 and diabetes had independent predictive value for early complications. There was a significant positive correlation between the difference of plasma IL-8 and the difference of CD11b / CD18 between the early complication group after PCI (r = 0.776, P <0.01). Conclusion: The incidence of early complications after PCI is related to the degree of inflammatory reaction before PCI. Patients with normal plasma IL-8 levels had an independent negative predictive value for early post-PCI complications.