阿霉素抗瘤谱广，但毒性大，临床应用受到限制。脂质体阿霉素不够稳定，而且脂质体不易进入肿瘤。聚乙二醇包裹的脂质体阿霉素（ＰＬＤ）性质稳定，在血循环中停留时间长，血浆清除率低，分布容积小。ＰＬＤ增加了阿霉素在肿瘤内的分布，提高了抗肿瘤活性，同时减少了对机体的毒性 Anti-tumor spectrum of adriamycin is broad, but its toxicity is great and its clinical application is limited. The liposomal doxorubicin is not stable enough and the liposomes do not easily enter the tumor. Polyethylene glycol-encapsulated liposomal doxorubicin (PLD) is stable, has a long residence time in the blood circulation, has a low plasma clearance and a small distribution volume. PLD increases the distribution of doxorubicin in tumors, increases antitumor activity, and reduces toxicity to the body.