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目的评价中医阴阳序贯疗法联合激素治疗卵巢早衰的临床疗效。方法检索1989年1月—2017年1月清华同方中国期刊全文数据库、维普中文科技期刊全文数据库、万方数据库中关于中医阴阳序贯疗法联合激素治疗卵巢早衰临床疗效的随机对照研究的相关文献。参照Jadad评分量表对纳入的文献进行方法学质量评价,利用Review Manager5.3进行Meta分析,P<0.05为差异有统计学意义。结果共7篇文献纳入本研究,中医阴阳序贯疗法联合激素治疗卵巢早衰在总有效率、Kupperman评分变化、雌二醇(Estradiol,E_2)水平的变化及卵泡刺激素(follicle-stimulating hormone,FSH)水平的变化方面均明显优于单纯激素替代疗法,差异均有统计学意义(均P<0.05)。结论中医阴阳序贯疗法联合激素治疗卵巢早衰的临床疗效确切,但由于纳入研究的文献数量偏少,质量偏低,仍需要更多高质量、多中心、大样本的临床随机对照实验研究加以验证。
Objective To evaluate the clinical efficacy of sequential treatment of yin and yang combined with hormones on premature ovarian failure. Methods A randomized controlled study on the clinical efficacy of sequential therapy of Chinese yin and yang combined with hormonal treatment of premature ovarian failure was searched from January 1989 to January 2017 in Tsinghua Tongfang Chinese Journal Full-text Database, VGP Chinese Science and Technology Periodical Full-text Database and Wanfang database. The Jadad scale was used to evaluate the methodological quality of the included articles. Meta-analysis was performed using Review Manager 5.3. P <0.05 was considered statistically significant. Results A total of 7 articles were included in this study. The changes of total effective rate, Kupperman score, Estradiol (E 2) level and follicle-stimulating hormone (FSH) ) Levels were significantly better than simple hormone replacement therapy, the differences were statistically significant (P <0.05). Conclusions Chinese medicine sequential therapy of yin and yang combined with hormonal treatment of ovarian premature ovarian failure has definite curative effect. However, more and more high quality, multicenter and large clinical randomized controlled trials are needed because of the small number and low quality of the included literature .