食管癌癌前病变的研究和认识是一个漫长而曲折的过程。慢性食管炎、白斑症、Plummer- vinson综合征和 Barrett食管等食管疾病曾被认为是癌前病变。但在我国食管癌高发区 ,它们的发病率并不高 ,与食管癌的发生似无因果关系。如慢性食管炎经 5年～ 1 0年随访观察 ,同正常食管上皮 Esophageal cancer precancerous lesions research and understanding is a long and tortuous process. Esophageal diseases such as chronic esophagitis, vitiligo, Plummervinson syndrome, and Barrett’s esophagus have been considered precancerous lesions. However, high incidence of esophageal cancer in our country, their incidence is not high, and causal relationship with the occurrence of esophageal cancer. Such as chronic esophagitis by 5 years ~ 10 years follow-up observation, with normal esophageal epithelium