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目的探讨梗阻性黄疽病人胆红素的毒性机理。方法采用质谱法测定梗阻性黄疽病人减黄术前后的红细胞膜脂变化。结果减黄术后两周,病人红细胞膜脂的长链脂肪酸、不饱和脂肪酸增多,双键含量增加,膜脂成分趋向正常。结论减黄术能改善梗阻性黄疽病人的红细胞膜结构与功能。
Objective To investigate the toxic mechanism of bilirubin in obstructive jaundice patients. Methods Mass spectrometry was used to determine the change of membrane lipid in patients with obstructive jaundice before and after subtraction of yellow. Results Two weeks after the operation, the long-chain fatty acids and unsaturated fatty acids of the erythrocyte membrane lipids increased, the double bond content increased, and the membrane lipid components tended to be normal. Conclusion Huangmai can improve the structure and function of erythrocyte membrane in patients with obstructive jaundice.