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目的探讨饮食钙和饮食草酸两因素对大鼠24小时尿草酸总排泄量和24小时尿钙总排泄量的影响。方法将24只大鼠随机分为低剂量钙组(A组)、中等剂量钙组(B组)及高剂量钙组(C组),连续喂养4 d,每组在4 d内分别依次给予剂量递减的饮食草酸。测量大鼠每天的24小时尿量、尿草酸浓度、尿钙浓度、尿肌酐浓度并计算24小时尿草酸总排泄量和24小时尿钙总排泄量。其中,尿草酸浓度用HPLC法检测,尿钙浓度和尿肌酐浓度用自动生化分析仪检测。用重复测量方差分析和多元方差分析对结果进行统计。结果对24小时尿草酸总排泄量在不同时间点比较,第3天和第1天相比下降(P=0.010),第4天和第1天相比下降(P=0.000),第4天和第2天相比下降(P=0.034),第4天和第3天相比下降(P=0.032),其余差异未见有统计学意义。对24小时尿钙总排泄量在不同时间点比较,第2天和第1天相比差异有统计学意义(P=0.037),其余差异未见有统计学意义(P>0.05)。结论 24小时尿草酸总排泄量随饮食钙摄入量提高而降低,随饮食草酸摄入量降低而降低。适当范围内补钙对24小时尿钙排泄量影响不大,而过度补钙可能会引起高钙尿症。
Objective To investigate the effects of dietary calcium and dietary oxalic acid on total 24-hour urine oxalic acid excretion and 24-hour urinary calcium excretion in rats. Methods Twenty-four rats were randomly divided into low dose calcium group (group A), middle dose calcium group (group B) and high dose calcium group (group C) Dose-reducing diet oxalic acid. The 24-hour urine output, urinary oxalate concentration, urinary calcium concentration and urinary creatinine concentration were measured and the total urinary oxalate excretion and 24-hour urinary calcium excretion were calculated. Among them, urinary oxalate concentration by HPLC method, urinary calcium concentration and urinary creatinine concentration with automatic biochemical analyzer. The results were statistically analyzed using repeated measures ANOVA and multivariate ANOVA. The results showed that total urinary oxalate excretion at 24 hours decreased at different time points compared with day 3 and day 1 (P = 0.010), decreased day 4 and day 1 (P = 0.000), day 4 (P = 0.034), decreased on the fourth day and the third day (P = 0.032), and the other differences were not statistically significant. The total urinary excretion of 24-hour urinary calcium at different time points compared to the second day and the first day was significantly different (P = 0.037), the other differences were not statistically significant (P> 0.05). Conclusions Total urinary oxalate excretion decreased with dietary calcium intake at 24 hours and decreased with dietary oxalic acid intake. Calcium within a reasonable range of 24-hour urinary calcium excretion has little effect, and excessive calcium may cause hypercalciuria.