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目的探讨短暂性脑缺血(TIA)患者血浆同型半胱氨酸(Hcy)、内皮素(ET)、一氧化氮(NO)、叶酸(FA)、维生素B12(VitB12)变化及临床意义。方法检测60例暂性脑缺血患者血浆中同型半胱氨酸、内皮素(ET)、一氧化氮(NO)、叶酸、维生素B水平,并与同期42例健康体检者进行了对照。结果短暂性脑缺血组血浆Hcy、ET显著高于对照组,且差别具有显著性(P<0.01);NO、FA、VitB12的水平低于对照组(P<0.01)。短暂性脑缺血患者中高血压患者Hcy高于血压正常患者。结论短暂性脑缺血患者血浆Hcy、ET浓度升高,检测血浆Hcy含量变化对于患者病情观察、预后判断具有重要意义,短暂性脑缺血患者服用FA和VitB12等制剂对于治疗和预防具有重要临床价值。
Objective To investigate the changes of plasma homocysteine (Hcy), endothelin (ET), nitric oxide (NO), folic acid (FA) and vitamin B12 (VitB12) in patients with transient ischemic attack (TIA) Methods The levels of plasma homocysteine, endothelin (ET), nitric oxide (NO), folic acid and vitamin B in 60 patients with transient ischemic attack were detected and compared with 42 healthy subjects in the same period. Results The plasma levels of Hcy and ET in transient ischemic group were significantly higher than those in control group (P <0.01). The levels of NO, FA and VitB12 were lower than those in control group (P <0.01). Patients with transient ischemic Hype Hypertension higher than normal blood pressure patients. Conclusion The plasma Hcy and ET levels are elevated in patients with transient ischemic attack. The detection of plasma Hcy levels is of great significance for the observation of patients’ condition and the prognosis. The patients with transient ischemic attack taking FA and VitB12 have important clinical and clinical benefits value.