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PEG10基因是由反转座子衍生而来的遗传印记基因,研究表明,PEG10是肝细胞癌(HCC)发生的重要促进作用之一,在绝大多数肝癌中特异性高表达,具有作为更有效的肝癌诊断标志物和基因治疗新靶点的潜力。本文概述PEG10基因与肝癌发生、发展和转移的关系及其作用与肝癌的机制,并对其前景进行展望,以期为肝癌的标志物诊断和基因靶向治疗的研究提供理论参考依据。
PEG10 gene is a retrotransposon derived from the genetic imprinting gene, studies have shown that PEG10 is one of the important role in promoting the development of hepatocellular carcinoma (HCC), which is highly expressed in the vast majority of liver cancer, with more effective The potential of liver cancer diagnostic markers and new targets for gene therapy. This article outlines the relationship between PEG10 gene and the occurrence, development and metastasis of hepatocellular carcinoma and its mechanism and the mechanism of hepatocellular carcinoma, and prospects its prospects in order to provide a theoretical reference for the diagnosis of liver cancer markers and gene-targeted therapies.