肠易激综合征(IBS)主要是以腹痛或者腹部不适伴排便习惯改变为主要症状的一种功能性疾病,根据罗马Ⅲ诊断标准,依据症状将IBS分为腹泻型(D-IBS)、便秘型(C-IBS)、混合型(M-IBS)及不确定型(U-IBS)~([1-2])。近年来研究发现,胃肠激素及炎性因子均参与了IBS的发病。酪酪肽(PYY)是一种对消化道多种生理功能有调节作用的胃肠激素,我们前期的动物实验研究发现,PYY水平与IBS发病存 Irritable Bowel Syndrome (IBS) is a functional disease mainly characterized by abdominal pain or abdominal discomfort with bowel habits. According to the diagnostic criteria of Rome Ⅲ, IBS is divided into diarrhea type (D-IBS), constipation C-IBS, M-IBS and U-IBS ~ ([1-2]). In recent years, studies have found that gastrointestinal hormones and inflammatory factors are involved in the pathogenesis of IBS. Cheese peptide (PYY) is a gastrointestinal hormone that has a regulatory effect on various physiological functions of the digestive tract. Our previous study on animal experiments found that the level of PYY was associated with the incidence of IBS