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目的观察太白米正丁醇与水提取部位对血瘀大鼠血液流变学的影响。方法将SD大鼠随机分为正常组、模型组、太白米正丁醇提取部位组、太白米水提取部位组及丹参滴丸组,予相应药物干预10d,并于末次给药前采用皮下注射0.1%盐酸肾上腺素复合冰水浴造成大鼠血瘀模型。实验结束,颈总动脉插管取血,采用全自动血液流变仪测定不同剪切力下全血黏度、血浆黏度及红细胞聚集指数。结果太白米正丁醇、水提取部位(10g生药/kg)对血瘀大鼠全血黏度、血浆黏度和红细胞聚集指数均有降低作用。结论太白米正丁醇、水提取部位对血液流变学异常有改善作用。
Objective To observe the effect of n-butanol and water extract of Taibai on hemorrheology in blood stasis rats. Methods Sprague-Dawley rats were randomly divided into normal group, model group, n-butanol extraction group, Taibaimi water extraction group and Danshen Diwan group. The rats were treated with the corresponding drugs for 10 days and subcutaneously Blood stasis model induced by 0.1% hydrochloric acid epinephrine combined with ice water bath in rats. At the end of the experiment, the common carotid arteries were cannulated for blood collection. The whole blood viscosity, plasma viscosity and erythrocyte aggregation index under different shear forces were measured by automatic hemorheological analyzer. Results Taibai rice n-butanol, water extract (10g crude drug / kg) on blood viscosity, plasma viscosity and erythrocyte aggregation index decreased. Conclusion Taibai rice n-butanol, water extraction site on the improvement of hemorheology abnormalities.