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目的了解肠道病毒在儿童中感染引起皮疹的情况,为预防控制手足口病在儿童中的流行提供依据。方法对212例手足口病儿童和50例非皮疹儿童开展流行病学调查并采集肛拭子标本,采用荧光定量RTPCR方法对262份肛拭子标本进行肠道病毒(其他EV、EV71、CA16)核酸检测。分析时采用病例对照研究。结果病例组中肠道病毒感染率为71.70%,明显高于对照组(26.00%)(χ2=36.30,P<0.01),其中EV71和CA16感染率分别为2.00%和4.00%;感染CA16和双重病毒感染的更易出现皮疹症状(χ2=33.19,P<0.01);2~3岁儿童和男性儿童感染肠道病毒的风险更高(χ2=23.37,P<0.01)。结论健康儿童中存在肠道病毒的隐性感染,开展手足口病流行病学和病原学研究,将有助于提出更好的预防和控制措施。
Objective To understand the situation of intestinal rashes caused by enterovirus infection in children and provide basis for prevention and control of HFMD in children. Methods A total of 212 children with HFMD and 50 non-rash children were enrolled in the epidemiological investigation and the samples of rectal swabs were collected. Twenty-four samples of rectal swabs were tested for intestinal virus (other EVs, EV71 and CA16) by fluorescence quantitative RTPCR. Nucleic acid test. Case-control studies were used in the analysis. Results The infection rate of enterovirus in case group was 71.70%, significantly higher than that in control group (26.00%) (χ2 = 36.30, P <0.01). The infection rates of EV71 and CA16 were 2.00% and 4.00% The virus infection was more likely to have rash (χ2 = 33.19, P <0.01). Children 2-3 years of age and men had a higher risk of acquiring enterovirus (χ2 = 23.37, P <0.01). Conclusion There are latent infections of enteroviruses in healthy children. To carry out epidemiological and etiological studies of hand, foot and mouth disease will help to propose better prevention and control measures.