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洋地黄类制剂用于临床治疗充血性心力衰竭,其治疗安全范围小,治疗量接近于中毒量,以往住院患者的中毒发生率是10～30%,中毒的死亡率为3～21%。为改变洋地黄类制剂的用法,降低其中毒发生率和死亡率,作者于1981年～1983年用地高辛维持量疗法治疗156例心力衰竭病人。临床分析结果证明:与“传统的洋地黄化”疗法对比,该法有效果好、显著降低中毒发生率和死亡率的优点。治疗中地高辛以0.375±0.125毫克/日维持量为
Digitalis preparations for the clinical treatment of congestive heart failure, the treatment of small safe range, the amount of treatment close to the amount of poisoning, in the past the incidence of poisoning in hospitalized patients was 10 to 30%, the mortality rate of poisoning was 3 to 21%. In order to change the usage of digitalis preparations and reduce their poisoning incidence and mortality, the authors treated 156 cases of heart failure patients with digoxin maintenance dose therapy from 1981 to 1983. Clinical analysis results show that: Compared with the “traditional digitalis” therapy, the method is effective and significantly reduce the incidence of poisoning and mortality advantages. In the treatment of digoxin to 0.375 ± 0.125 mg / day maintenance