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目的:探讨慢性重型乙型肝炎血清甲胎蛋白(AFP)、胆碱酯酶(CHE)、凝血酶原活动度(PA)、总胆红素(TBIL)、重型肝炎分期等指标与预后的关系。方法:检测慢性重型乙型肝炎148例入院时AFP、TBIL、CHE、PA的水平,分析其与预后和肝炎分期的关系。结果:本组患者临床治愈好转率31.8%。治愈好转组与无效组入院时AFP、PA水平比较,差异显著(P<0.05);重型肝炎早期患者与晚期患者入院时AFP水平比较,差异显著(P<0.05)。结论:AFP、PA、重型肝炎分期是判断重型乙型肝炎预后的重要及可靠指标,且AFP、PA的信息反应较早,更有助于进行早期判断预后。
Objective: To investigate the relationship between prognosis and serum levels of AFP, CHE, PA, TBIL and staging of severe hepatitis in patients with chronic severe hepatitis B . Methods: The levels of AFP, TBIL, CHE and PA in 148 cases of chronic severe hepatitis B admitted to hospital were detected, and their relationship with prognosis and hepatitis stage were analyzed. Results: The clinical cure rate was 31.8% in this group. There was significant difference (P <0.05) in the level of AFP and PA between the cured and inactive patients admitted to hospital; the difference was significant (P <0.05) between the level of AFP and the level of AFP in hospitalized patients with severe hepatitis. Conclusion: AFP, PA, severe hepatitis staging is an important and reliable indicator to judge the prognosis of severe hepatitis B, and the information of AFP, PA response earlier, more conducive to early prognosis.