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12例患者中10例为普通变异性免疫缺陷病,2例为性联低丙种球蛋白血症。其中4例虽常规使用IgG肌注仍有慢性肺部疾病发生。5例用常规IgG治疗1—7年,肺部疾病逐渐恶化。另3例均有慢性肺部疾病未经治疗。随机将患者分为两组(每组6例),分别接受IVISG0.2g/kg/或0.6g/kg,每月一次静脉输注,治疗6个月后,两组IVISG剂量互换,继续治疗6个月。12例患者共输注IVISG144次。前6个月接受0.6g/kg剂量的6例患者于2—4月内血清IgG逐渐增至500mg/dl以上,当改为0.2g/kg后,其中4例血清IgG迅速下降,第3—4月后6例均降至500mg/dl以下。前6个月接受0.2g/kg的6例中无1例血清IgG达500mg/dl者。轻度感染共43次,大多数为呼吸道感染,其中24次发生于小剂量治疗期间,19次发生于大剂量治疗期间,显示两者无明显差异。若按血
Of the 12 patients, 10 were normal variant immunodeficiency disease and 2 were sexually associated hypogammaglobulinemia. Of the four cases, there were still chronic pulmonary diseases in the routine use of IgG intramuscular injection. Five patients treated with conventional IgG 1-7 years, lung disease gradually worsened. The other three cases had chronic lung disease untreated. The patients were randomly divided into two groups (6 in each group) receiving IVISG0.2g / kg / or 0.6g / kg intravenously once a month. After 6 months of treatment, the IVISG doses were exchanged between the two groups and continued treatment 6 months. Twelve patients received IVISG144 times in total. In the first 6 months of 6 patients receiving 0.6g / kg dose of serum IgG increased gradually from 2 to 4 months to 500mg / dl or more, when changed to 0.2g / kg, of which 4 cases of serum IgG decreased rapidly, the first 3- After April 6 cases were reduced to 500mg / dl below. In the first 6 months to accept 0.2g / kg in 6 cases, no case of serum IgG 500mg / dl. A total of 43 mild infections, most of them respiratory infections, occurred 24 times during the low-dose treatment and 19 during the high-dose treatment, showing no significant difference between the two. If by blood