论文部分内容阅读
目的:探讨血清前列腺特异性抗原(PSA)水平与单光子发射型计算机断层扫描(SPECT)骨显像分级的关系及两者在前列腺癌(PCa)患者骨转移中的诊断价值。方法:回顾性分析2013年1月1日至2015年12月31日广西医科大学附属肿瘤医院收治的54例PCa患者的SPECT骨显像特征和血清PSA水平。结果:54例PCa患者SPECT骨显像中,骨转移发生率为66.67%(36/54),其中单发病灶3例,骨转移部位以脊柱、骨盆最常见。PCa骨显像阳性组与阴性组血清PSA水平比较,差异有统计学意义(Z=-5.092,P<0.05)。PSA≤10μg/L的7例患者中,仅有1例发生骨转移(14.29%),PSA>100μg/L的15例患者均出现骨转移。SPECT骨显像分级与血清PSA水平存在正相关关系(r=0.748,P<0.05)。以PSA>20μg/L作为临界值,骨转移诊断的准确性最高(85.19%),灵敏度和特异度分别为88.89%、77.78%。结论:SPECT骨显像分级与血清PSA高度相关,PSA水平随着骨显像分级升高而升高;当PCa患者PSA水平>20μg/L时,应行核素骨显像检查以提高PCa骨转移的检出率。
Objective: To investigate the relationship between serum PSA and SPECT bone imaging and the diagnostic value of both in bone metastasis of prostate cancer (PCa). Methods: The characteristics of SPECT bone marrow biopsy and serum PSA levels in 54 patients with PCa who were admitted to Cancer Hospital of Guangxi Medical University from January 1, 2013 to December 31, 2015 were retrospectively analyzed. Results: In 54 cases of PCa, the incidence of bone metastasis was 66.67% (36/54) in SPECT bone scintigraphy. Among them, 3 cases had single lesion and the spine and pelvis were the most common bone metastases. PCa bone imaging positive group and negative serum PSA levels, the difference was statistically significant (Z = -5.092, P <0.05). Of the 7 patients with PSA≤10 μg / L, only 1 had bone metastases (14.29%), and 15 patients with PSA> 100 μg / L had bone metastases. SPECT bone imaging grading and serum PSA levels there is a positive correlation (r = 0.748, P <0.05). With PSA> 20μg / L as the critical value, the diagnostic accuracy of bone metastasis was the highest (85.19%), the sensitivity and specificity were 88.89% and 77.78% respectively. CONCLUSIONS: SPECT bone imaging grade is highly correlated with serum PSA, PSA level increases with the increase of bone imaging grade. When PSA level of PCa is> 20μg / L, radionuclide bone imaging should be performed to improve PCa bone The detection rate of metastasis.