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目的:探讨中西医结合对哮喘儿童Th1/Th2细胞因子影响的研究。方法:随机分为对照组和治疗组,对照组用孟用鲁司特片2~5岁4 mg,6~14岁5 mg,每晚1次睡前口服。治疗组在对照组基础上加中药平喘汤,每天1剂,水煎分4~6次服。共8周。另设健康儿童组做对照。治疗前后采静脉血3 mL,用ELISA法检测IL-4,IL-13和IFN-γ水平。结果:治疗前两组哮喘疗患儿IL-4,IL-13水平均高于健康组,而IFN-γ水平则低于健康组,两者差异有显著性(P<0.01,P<0.05)。8周后治疗组IL-4,IL-13水平下降、IFN-γ水平升高,与对照组比较,差异有显著性(P<0.05)。结论:中西医结合治疗儿童哮喘可显著下调IL-4,IL-13及上调IFN-γ水平,从而减轻气道炎症,有效地防止哮喘的发作。
Objective: To investigate the effect of traditional Chinese and western medicine on Th1 / Th2 cytokines in asthmatic children. Methods: The patients were randomly divided into control group and treatment group. In the control group, patients treated with montelukast 2 mg to 5 years and 5 mg 6 to 14 years old were dosed orally before going to bed at night. The treatment group in the control group based on the traditional Chinese medicine asthma soup, 1 day, decoction points 4 to 6 times service. A total of 8 weeks. Another set of healthy children as a control. Venous blood 3 mL before and after treatment, IL-4, IL-13 and IFN-γ levels were detected by ELISA. Results: The levels of IL-4 and IL-13 in children with asthma before treatment were higher than those in healthy group, while the levels of IFN-γ were lower than those in healthy group (P <0.01, P <0.05) . After 8 weeks, the level of IL-4 and IL-13 in the treatment group decreased and the level of IFN-γ increased. Compared with the control group, the difference was significant (P <0.05). Conclusion: Integrative Chinese and Western medicine treatment of asthma in children can significantly reduce IL-4, IL-13 and up-regulate IFN-γ levels, thereby reducing airway inflammation and effectively prevent the onset of asthma.