为了探讨柠檬苦素类似物对乳腺癌细胞MCF 7生长抑制和对细胞周期的影响 ,应用MTT法和流式细胞仪检测癌细胞株生长和细胞周期 .结果显示柠檬苦素类似物能明显抑制MCF 7的生长 ,抑制率高于 70 % ,并随作用时间和剂量增加其效果增强 ;柠檬苦素可以影响细胞周期G2 /M期 .柠檬苦素类似物可以明显抑制MCF 7的增殖 ,并有可能是通过阻滞细胞在G2 /M期而降低其生长能力 . To investigate the effect of limonoid analogs on the growth inhibition and cell cycle of breast cancer cells, MTT assay and flow cytometry were used to detect the growth and cell cycle of the cancer cells. The results showed that the limonoid analogues can significantly inhibit the MCF. The growth rate of 7 is higher than 70%, and its effect is enhanced with the increase of action time and dose; Limonoid can affect cell cycle G2 / M phase. Limonoid analogue can significantly inhibit the proliferation of MCF-7, and may be By blocking cells in the G2 / M phase and reduce their growth ability.