论文部分内容阅读
目的:观察eritoran对大鼠肾脏缺血再灌注损伤模型的。方法:建立SD大鼠缺血再灌注模型,给予eritoran治疗而对照组给予生理盐水治疗,观察各组的肾功能情况、肾组织光镜病理,并采用核糖核酸酶保护测定检测肾组织炎症因子/趋化因子的表达。结果:与模型组相比,eritoran预处理可显著改善大鼠的肾功能,减轻缺血再灌注引起的肾小管损伤,减轻肾组织病变,减少肾组织单核细胞浸润并下调多种炎症因子的表达(TNF-α,IL-6,IL-1β和MCP-1)。结论:本研究证实通过eritoran抑制Toll样受体4,可减轻大鼠肾脏缺血再灌注损伤中的炎症反应,减轻肾脏缺血再灌注损伤,eritoran可望成为肾脏I/R损伤的新治疗手段。
Objective: To observe the effect of eritoran on renal ischemia-reperfusion injury in rats. Methods: The model of ischemia-reperfusion in SD rats was established. Eritoran treatment was given to the rats in the control group and normal saline was given to the control group. Renal function, pathological changes in renal tissues were observed. The renal tissue inflammatory factor / Chemokine expression. Results: Compared with the model group, eritoran preconditioning could significantly improve renal function, alleviate renal tubular injury induced by ischemia / reperfusion, alleviate renal pathological changes, reduce infiltration of renal tissue monocytes and down-regulate a variety of inflammatory cytokines (TNF-α, IL-6, IL-1β and MCP-1). CONCLUSIONS: This study demonstrates that inhibition of Toll-like receptor 4 by eritoran attenuates the inflammatory response in renal ischemia-reperfusion injury in rats and reduces renal ischemia-reperfusion injury, with eritoran expected to be a new treatment for renal I / R injury .