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为了研究血浆各种脂质水平与冠状动脉硬化程度的关系,将132例病人按冠脉造影结果分为冠心病组(狭窄≥50％)83例,与非冠心病组(狭窄<50％)49例,并按冠状动脉狭窄程度分级,将各支冠脉级别累加为冠脉狭窄程度记分(CSS)。同时检测各项血脂指标[Lp(a)、TC、TG、HDL-C、LDL-C、apoAI、apoB、TC/HDL-C、apoAI/apoB]。结果表明,患者的年龄、Lp(a)、LDL-C、TG、TC、HDL-C、TC/HDL-C、apoAI/apoB和apoB与非冠心病组比较差异均有显著性。多元相关及逐步回归分析表明,CSS与年龄、Lp(a)、TC/HDL-C、apoB水平呈明显正相关(均P<0.01)。排除年龄因素的影响,血浆Lp(a)、TC/HDL-C及apoB是冠心病的独立危险因素,对于预测冠心病及病变程度较其它血脂指标更为敏感,具有更大的临床价值。
In order to study the relationship between plasma lipid levels and the severity of coronary atherosclerosis, 132 patients were divided into coronary heart disease group (≥50%), coronary artery disease (83 cases) and non-coronary heart disease group (≤50%), Forty-nine patients were divided into two groups according to the degree of coronary artery stenosis. The coronary arteries were summed up as coronary stenosis score (CSS). At the same time, all the blood lipid indicators [Lp (a), TC, TG, HDL-C, LDL-C, apoAI, apoB, TC / HDL-C, apoAI / apoB] were detected. The results showed that there were significant differences in age, Lp (a), LDL-C, TG, TC, HDL-C, TC / HDL-C, apoAI / apoB and apoB between the two groups. Multiple correlation and stepwise regression analysis showed that there was a significant positive correlation between CSS and age, Lp (a), TC / HDL-C and apoB levels (all P <0.01). Excluding the influence of age, plasma Lp (a), TC / HDL-C and apoB were independent risk factors for coronary heart disease, which were more sensitive and predictive of coronary heart disease and pathological changes than other blood lipid indicators.