氯丁二烯(2—氯—1,3—丁二烯)是合成橡胶的重要原料。近年来,许多作者采用不同的实验方法发现氯丁二烯对生物有较强的诱变性,因而其对人体的诱变作用日益受到重视。有些作者曾报道氯丁二烯可引起接触工人外周血淋巴细胞染色体畸变率的升高。但采用姊妹染色单体互换(SCE)检测和微核检测的方法观察氯丁二烯对人体 Chloroprene (2-chloro-1,3-butadiene) is an important raw material for synthetic rubber. In recent years, many authors use different experimental methods to find that chloroprene has a strong mutagenicity to the organism, so its mutagenic effect on the human body has been paid more and more attention. Some authors have reported that chloroprene can cause an increase in chromosome aberrations in peripheral blood lymphocytes exposed to workers. However, the use of sister chromatid exchange (SCE) test and micronucleus test method for the observation of chloroprene on the human body