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甲氰咪胍治疗上消化道溃疡,在全世界已得到广泛应用,并取得了良好效果。本文就国内外近年来甲氰咪胝的非溃疡性临床应用,作一文献综述。一、上消化道出血暴发性肝功能衰竭时,消化道粘膜可发生应激性溃疡。同时有严重的凝血障碍,消化道出血率常超过50％。正常情况下,组织胺由肝脏代谢。肝功衰竭时,大量组织胺不能及时清除而作用于胃粘膜靶细胞中的H_2受体,使胃酸分泌大增,促使溃疡发生,继而造成周围小血管溃破出血。近年来,Lambert、Macdougall报导用甲氰咪胍防止肝功衰竭的上消化道出血有效。静点甲氰咪胍和甲硫咪胺(metiamide)150mg(每小时100mg)或口服1g,可防止和治
Cimetidine in the treatment of upper gastrointestinal ulcers, has been widely used around the world, and achieved good results. This article reviews the non-ulcer clinical application of cimetidine at home and abroad in recent years. First, the upper gastrointestinal bleeding fulminant liver failure, gastrointestinal mucosa can occur stress ulcer. At the same time a serious coagulopathy, gastrointestinal bleeding often more than 50%. Normally, histamine is metabolized by the liver. When liver failure, a large number of histamine can not be promptly removed and the role of H 2 receptors in gastric mucosal target cells, so that greatly increased gastric acid secretion, prompting the occurrence of ulcers, resulting in peripheral small vessel ulceration bleeding. In recent years, Lambert, Macdougall reported cimetidine to prevent upper gastrointestinal bleeding in liver failure. Static cimetidine and metiamide 150mg (100mg / hour) or oral 1g, to prevent and cure