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采用抗人肺腺癌单克隆抗体KM-93对正常人涎腺、胎儿涎腺和多形性腺瘤进行免疫组织化学研究。单抗KM-93与浆液性细胞及部分导管细胞呈阳性反应,与肌上皮细胞、粘液细胞及多形性腺瘤中的粘液软骨样组织无反应。多形性腺瘤中可见阳性细胞形成腺泡样细胞团,也显示出阳性细胞具有的分泌功能。作者认为单克隆抗休KM-93阳性细胞具有某些浆液性细胞的特点,在研究涎腺和涎腺肿后的组织结构及分化方面具有一定的使用价值。
Human salivary gland, fetal salivary gland and pleomorphic adenoma were immunohistochemically studied with anti-human lung adenocarcinoma monoclonal antibody KM-93. McAb KM-93 and serous cells and some ductal cells positive reaction, and myoepithelial cells, mucoid cells and pleomorphic adenoma mucoid cartilage-like tissue no reaction. In pleomorphic adenomas, positive cells were observed to form alveolar-like cell mass, which also showed the secretion function of positive cells. The authors believe that the monoclonal anti-rest KM-93 positive cells have the characteristics of some serous cells in the study of salivary gland and salivary gland after the organization and differentiation has a certain value.