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目的:分析发生胃粘膜病变或炎症反应的程度与患者感染幽门螺杆菌(Helicobacter Pylori,HP)的关联性。方法:将2013年1月至2015年12月在某院接受体检的89例受检者与某院收治的95例慢性胃炎和消化性溃疡患者作为研究对象。将其中89例受检者纳入观察组,将95例慢性胃炎或消化性溃疡患者纳入对照组。对两组患者进行血清抗体检查、HP粪抗原(HPSA)检查、胃镜检查与组织学检查,然后对比分析两组受检者检出HP感染的情况、对照组患者的临床症状与发生HP感染的关联性、两组受检者发生胃部病变及胃部炎症反应的程度与发生HP感染的关联性。结果:与观察组受检者相比,对照组患者的HP检出率略高,但差异无统计学意义(χ2=1.60,P=0.21)。在对照组患者中,61例HP感染者与34例无HP感染者腹痛、腹胀、嗳气、恶心、返酸、胃部烧灼感、纳差和口臭的发生率相比较差异无统计学意义(P>0.05),其各症状的评分相比较差异无统计学意义(P>0.05)。两组受检者中发生胃粘膜病变者其病变的程度越重,其HP感染的发生率越高。两组受检者中发生胃部炎症反应者其病变的程度越重,其HP感染的发生率越高。结论:随着患者胃粘膜病变或炎症反应的加重,其HP感染的发生率可逐渐增高。
OBJECTIVE: To analyze the association between the degree of gastric mucosal lesion and inflammatory reaction and Helicobacter Pylori (HP) infection in patients. Methods: A total of 95 patients with chronic gastritis and peptic ulcer admitted to our hospital from January 2013 to December 2015 were enrolled in this study. 89 subjects were included in the observation group, 95 cases of chronic gastritis or peptic ulcer patients were included in the control group. Serum antibody test, HP fecal antigen (HPSA) test, gastroscopy and histological examination were performed on the two groups of patients, and then compared the detection of HP infection in two groups of patients, the clinical symptoms of patients in the control group and HP infection Correlation, two groups of subjects with gastric lesions and gastric inflammation caused by the degree of occurrence of HP infection associated. Results: The detection rate of HP in the control group was slightly higher than that in the observation group, but the difference was not statistically significant (χ2 = 1.60, P = 0.21). In the control group, there was no significant difference in the incidence of abdominal pain, abdominal distension, belching, nausea, acid reflux, stomach burning sensation, anorexia and bad breath among 61 HP infected patients and 34 non-HP infected patients (P > 0.05), the score of each symptom was no significant difference (P> 0.05). The incidence of gastric lesion in the two groups of subjects was more severe, the higher the incidence of HP infection. In both groups, the more severe the lesion was, the higher the incidence of HP infection was. Conclusion: With the increase of gastric mucosal lesions or inflammatory reaction, the incidence of HP infection may be gradually increased.