最近几年,普遍认为大多数β-肾上腺能受体阻滞剂能够改变血浆脂蛋白浓度。目前有充分的证据表明,心得安在许多接受治疗者中,使血浆极低密度脂蛋白(VLDL)浓度增高,而高密度脂蛋白胆固醇(HDL-C)浓度降低。在使用其它非选择性β阻滞剂如苏特罗、萘羟心安、噻吗心安,以及使用β_1选择性药物如氨酰心安和美多心安等治疗期间亦已得到类似结果. In recent years, it is generally accepted that most beta-adrenergic receptor blockers can alter plasma lipoprotein concentrations. There is well-documented evidence that propranolol increases the plasma concentration of very low density lipoprotein (VLDL) and decreases the concentration of high-density lipoprotein cholesterol (HDL-C) in many patients undergoing treatment. Similar results have also been obtained during the treatment with other non-selective beta blockers such as strontium, nafion, timolol, and the use of beta-1 selective drugs such as Atenolol and Metoprolol.