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目的观察中西医结合治疗糖尿病胃轻瘫的疗效,为改善糖尿病性胃轻瘫临床症状提供理伦依据。方法选择2014年7月—2017年7月北京市房山区中医医院门诊及住院处的146例糖尿病胃轻瘫患者作为研究对象,随机分为对照组和治疗组,每组73例。对照组常规控制血糖,并口服多潘立酮10 mg,3次/d。治疗组在对照组的基础上给予自拟养胃汤治疗,1剂/d,水煎取汁300 ml,分2次温服。治疗4周后,比较两组临床疗效、症状积分、血糖及胃肠动力指标。结果 4周后治疗组总有效率91.78%,对照组总有效率67.12%,差异有统计学意义(P<0.05);治疗组在改善胃脘胀满、早饱、恶心、呕吐、食欲不振、嗳气等症状方面明显优于照组,差异均有统计学意义(P<0.05或P<0.01)。治疗组在治疗后餐后2 h血糖及糖化血红蛋白水平均低于对照组,差异均有统计学意义(均P<0.05)。胃肠动力改善方面,治疗组总有效率为89.04%,显著高于对照组的63.01%,差异有统计学意义(P<0.05)。结论中西医结合治疗糖尿病性胃轻瘫能够改善临床症状,提高治疗效果,值得临床应用。
Objective To observe the therapeutic effect of integrated traditional Chinese and western medicine on diabetic gastroparesis and to provide Riemannian evidence to improve the clinical symptoms of diabetic gastroparesis. Methods From July 2014 to July 2017, 146 cases of diabetic gastroparesis in outpatient department and inpatient department of Fangshan District Chinese Medicine Hospital in Beijing were randomly divided into control group and treatment group, with 73 cases in each group. The control group routinely controlled blood glucose, and oral domperidone 10 mg, 3 times / d. On the basis of the control group, the treatment group was given self-made Yangwei Decoction treatment, 1 dose / d, water decoction 300 ml, divided into 2 times warm clothes. After 4 weeks of treatment, the clinical efficacy, symptom score, blood glucose and gastrointestinal motility were compared between the two groups. Results After 4 weeks, the total effective rate was 91.78% in the treatment group and 67.12% in the control group, the difference was statistically significant (P <0.05) Qi and other symptoms were significantly better than the control group, the differences were statistically significant (P <0.05 or P <0.01). After treatment, the levels of blood glucose and glycosylated hemoglobin in the treatment group were lower than those in the control group 2 h after treatment, the difference was statistically significant (P <0.05). Gastrointestinal motility improved, the total effective rate was 89.04% in the treatment group, significantly higher than 63.01% in the control group, the difference was statistically significant (P <0.05). Conclusion Integrative treatment of diabetic gastroparesis can improve clinical symptoms and improve the therapeutic effect, it is worth clinical application.