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目的 为探讨血清白细胞介素2(IL—2)及肿瘤坏死因子(TNF)水平变化对口腔恶性肿瘤的临床意义。方法 检测了37例口腔恶性肿瘤患者血清IL—2及TNF的水平,并进行手术前后动态观察。结果 发现血清IL—2水平明显低于正常对照组(P<0.01),且血清IL—2水平与肿瘤临床分期有关,手术治疗后血清IL—2水平明显回升,与治疗前相比有显著差异(P<0.01),而血TNF水平与正常人无差异,手术前后也无明显变化。结论 提示口腔恶性肿瘤患者血清IL—2含量的检测对反映机体肿瘤免疫水平及早期诊断具有一定的参考价值,可作为肿瘤免疫监视的一个客观指标。
Objective To investigate the clinical significance of serum interleukin 2 (IL-2) and tumor necrosis factor (TNF) levels in oral malignancies. Methods Serum levels of IL-2 and TNF were measured in 37 patients with oral malignant tumor and their dynamic changes were observed before and after operation. The results showed that serum IL-2 level was significantly lower than that of the normal control group (P <0.01), and the level of serum IL-2 was related to the clinical stage of the tumor. Serum IL-2 level rose significantly after operation, with significant difference (P <0.01). However, there was no difference between the levels of TNF and TNF in normal people. Conclusions The detection of serum IL-2 level in patients with oral malignant tumors suggests that it may provide a reference value for reflecting the level of tumor immunity and early diagnosis of oral cancer, and can be used as an objective indicator of tumor immune surveillance.