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目的探讨依达拉奉(Edaravone)和凯时注射液(Alprostadil injection)联合应用对治疗急性脑梗死的临床疗效。方法收集2011年1月至2013年1月于四川省自贡市精神卫生中心神经内科住院治疗的急性脑梗死患者120例为研究对象,随机分为治疗组(n=60)和观察组(n=60),观察组患者除给予神经内科的常规治疗外,同时应用依达拉奉注射液治疗;治疗组患者在观察组患者治疗的基础上加用凯时注射液治疗,疗程均为2周,分析两组患者的临床疗效和神经功能的恢复情况。结果经过1个疗程恢复,治疗组患者的临床总有效率为90.00%,高于观察组的71.66%,差异有统计学意义(P<0.05);治疗组患者的神经系统功能恢复情况显著优于观察组,差异有统计学意义(P<0.05)。两组患者治疗前后血清补体C3和高敏C反应蛋白(hsˉCRP)均显著降低,且差异有统计学意义(P<0.05);经比较,治疗组治疗后的C3及hsˉCRP水平(1.11±0.12)g/L和(6.77±3.23)g/L,均显著低于观察组,差异有统计学意义。结论依达拉奉联合凯时注射液治疗急性脑梗死患者,不仅可以提高临床治疗效果,而且有助于神经系统功能的恢复,治疗过程安全、可靠,值得借鉴。
Objective To investigate the clinical efficacy of edaravone and Alprostadil injection in the treatment of acute cerebral infarction. Methods A total of 120 acute cerebral infarction patients hospitalized in the Department of Neurology, Mental Health Center, Zigong City, Sichuan Province from January 2011 to January 2013 were enrolled in this study. Patients were randomly divided into treatment group (n = 60) and observation group (n = 60). Patients in the observation group were treated with edaravone injection in addition to the conventional treatment of neurology. Patients in the treatment group were treated with Kai Shi injection on the basis of the treatment of the observation group. The courses of treatment were 2 weeks, Analysis of two groups of patients with clinical efficacy and recovery of neurological function. Results After a course of recovery, the total effective rate of the treatment group was 90.00%, which was higher than that of the observation group (71.66%), the difference was statistically significant (P <0.05). The recovery of nervous system function of the treatment group was significantly better than that of the observation group Observation group, the difference was statistically significant (P <0.05). Serum complement C3 and high-sensitivity C-reactive protein (hs-CRP) were significantly decreased in both groups before and after treatment (P <0.05). After treatment, C3 and hsˉCRP levels in the treatment group were 1.11 ± 0.12 g / L and (6.77 ± 3.23) g / L, both significantly lower than the observation group, the difference was statistically significant. Conclusion The combination of edaravone and Kay Shi injection in patients with acute cerebral infarction can not only improve the clinical curative effect, but also help to restore the function of the nervous system. The treatment process is safe and reliable, and it is worth learning from.