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目的:探讨前列腺特异性抗原(prostate specific antigen, PSA) 4~10μg/L患者前列腺癌检出率及与年龄和病理分级的相关性.方法:回顾性收集2011年1月至2017年12月仁寿县人民医院收治的213例PSA 4~10μg/L患者的相关资料,所有患者均行经直肠超声引导下前列腺穿刺活检,计算前列腺癌检出率,比较各年龄组、病理分级与检出率的相关性.结果: 本组213例PSA4~10μg/L患者中,穿刺活检阳性患者50例,阳性检出率23. 5% .穿刺阳性患者PSA(8. 11 ± 0. 53)μg/L,穿刺阴性患者PSA(6. 55 ± 0. 62)μg/L,两组比较差异有统计学意义( t=16. 075, P0. 05).结论:随着年龄的增加,PSA4~10μg/L患者中,前列腺癌穿刺阳性检出率也相应增高,年龄可以作为PSA4~10μg/L低水平患者前列腺癌筛查和诊断的重要参考指标.“,”To investigate the correlation between prostate cancer detection rate and age and that between the prostate cancer detection rate and pathological grading in patients with prostate specific antigen (PSA) 4-10μg/L. Methods: A retrospective study of 213 patients with PSA 4-10μg/L admitted to our hospital from January 2011 to December 2017 was conducted. All patients underwent transrectal ultrasound guided prostate needle biopsy, and the detection rate of prostate cancer was calculated. The correlation between the detection rate and age or pathological grading was compared. Results: Fifty out of 213 biopsy samples was positive, and the positive rate was 23. 5% . PSA of patients with positive results in needle biopsy was (8. 11+0. 53)ug/L, and that of patients with negative results in needle biopsy was (6. 55 +0. 62) ug/L. Difference between the two groups was significant (t =16. 075, P 0. 05). Conclusion: Among patients with PSA 4 -10μg/L, the detection rate of prostate cancer in patients with positive results in prostate needle biopsy increase with the increase of age. Age can be an impor-tant reference for screening and diagnosis of prostate cancer in patients with PSA 4-10 ug/L.