用姐妹染色单体交换(SCE)测试技术,在离体培养条件下研究了不同浓度氟化钠(NaF)对人、兔外周血淋巴细胞的影响。在NaF浓度为0.1、1、10、100μg/ml时与对照组比较,未见SCE有增高现象。活体实验中,兔饮用水中含上述NaF浓度5周后,亦未见SCE增高。离体与活体实验结果一致。未见NaF可诱发SCE增高。作者结合其他实验结果分析,认为我国目前饮水卫生标准中的氟化物(以F计)浓度(1mg/l),从诱变性来看,属安全无害。 The effects of different concentrations of sodium fluoride (NaF) on human peripheral blood lymphocytes and rabbit peripheral blood lymphocytes were studied in vitro using the Sister Chromatid Exchange (SCE) assay. When NaF concentration was 0.1, 1, 10, 100μg / ml, there was no increase of SCE compared with the control group. In vivo experiments, rabbits drinking water containing the above-mentioned NaF concentration for 5 weeks, nor SCE increased. In vitro and in vivo experiments are consistent. No NaF can induce SCE increased. Based on the analysis of other experimental results, the author thinks that fluoride (F) concentration (1mg / l) in drinking water hygiene standard in our country is safe and harmless in terms of mutagenicity.