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目的探讨并比较复方环丙孕酮联合盐酸二甲双胍和复方环丙孕酮联合马来酸罗格列酮治疗多囊卵巢综合征的临床疗效。方法选取我院2009年3月至2012年7月治疗的150例多囊卵巢综合征患者,随机分为A组和B组,每组75例。A组给予复方环丙孕酮联合盐酸二甲双胍治疗,B组给予复方患病孕酮联合马来酸罗格列酮治疗,治疗3个月后同时给予克罗米芬进行促排卵治疗,疗程结束后观察比较两组用药前后黄体生成素(LH)、LH/卵泡刺激素(FSH)、睾酮(T)、胰岛素抵抗(IR)、体重指数(BMI)以及促排卵治疗后的排卵率。结果 T、LH、LH/FSH、IR以及双侧卵巢的卵泡数均比用药前明显降低(P<0.05),组间差异无统计学意义;B组患者的T、IR改善情况明显优于A组(P<0.05);A组治疗后体重指数明显下降,有统计学意义(P<0.05),且显著优于B组(P<0.05);促排卵治疗后A、B两组的排卵率分别为84.0%,78.7%,明显高与用药前(P<0.05),组间比较差异无统计学意义。结论两种治疗方法在临床中治疗多囊卵巢综合征均取得了良好的治疗效果,且两组用药各有其优势,临床用药时需根据患者症状、体征合理运用,以取得更好的治疗效果。
Objective To investigate and compare the clinical curative effect of compound cyproterone combined with metformin hydrochloride and compound cyproterone combined with rosiglitazone maleate in the treatment of polycystic ovary syndrome. Methods 150 cases of PCOS treated in our hospital from March 2009 to July 2012 were randomly divided into A group and B group, with 75 cases in each group. Group A was given compound cyproterone combined with metformin hydrochloride, Group B was given compound progesterone combined with rosiglitazone maleate. After 3 months of treatment, clomiphene was given concurrently for ovulation induction. After the treatment, the observation and comparison were made The LH, LH / FSH, T, IR, BMI and ovulation rate after ovulation induction were measured before and after treatment. Results The number of follicles in T, LH, LH / FSH, IR and bilateral ovary were significantly lower than those before treatment (P <0.05), and there was no significant difference between the two groups. The improvement of T and IR in group B was better than that of A (P <0.05). The body mass index of group A decreased significantly after treatment (P <0.05), and was significantly better than that of group B (P <0.05). The ovulation rate of group A and B after ovulation induction Respectively 84.0%, 78.7%, significantly higher and before treatment (P <0.05), no significant difference between the two groups was statistically significant. Conclusions Both treatments have achieved good therapeutic effect in the treatment of PCOS. The two groups of drugs have their own advantages. The clinical treatment should be based on the symptoms and signs of the patients so as to obtain better therapeutic effects .