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目的:观察脑脊液置换术联合尼莫地平治疗动脉瘤性蛛网膜下腔出血后脑血管痉挛的效果。方法:将106动脉瘤性蛛网膜下腔出血后脑血管痉挛患者按入院单双日随机分为两组,每组各53例,对照组患者给予常规治疗,治疗组在对照组基础上给予脑脊液置换术联合尼莫地平进行治疗,比较两组患者的治疗效果。结果:治疗1个月后,治疗组患者总有效率明显优于对照组,两组比较差异具有统计学意义(P<0.05);治疗组患者GOS评分优于对照组患者,差异均具有统计学意义(P<0.05);治疗后两组间患者大脑中动脉流速比较差异有统计学意义(P<0.05)。结论:脑脊液置换术联合尼莫地平可迅速改善动脉瘤性蛛网膜下腔出血后脑血管痉挛患者的临床症状,减少患者并发症的发生,提高临床治疗效果,值得临床推广和应用。
Objective: To observe the effect of cerebrospinal fluid replacement combined with nimodipine on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Methods: 106 patients with aneurysmal subarachnoid hemorrhage after cerebral vasospasm were randomly divided into two groups on the day of hospital admission, with 53 patients in each group. The patients in the control group were given routine treatment. The patients in the treatment group were given cerebrospinal fluid replacement Combined with nimodipine, the treatment effect was compared between the two groups. Results: After 1 month of treatment, the total effective rate of the treatment group was significantly better than that of the control group, the difference between the two groups was statistically significant (P <0.05); the GOS score of the treatment group was better than that of the control group, the differences were statistically (P <0.05). There was significant difference in the middle cerebral artery velocity between the two groups after treatment (P <0.05). Conclusion: Cerebrospinal fluid replacement combined with nimodipine can rapidly improve the clinical symptoms of patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhage, reduce the incidence of complications and improve the clinical therapeutic effect, which is worthy of clinical promotion and application.