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除酒精外,与药物有关的急性胰腺炎罕见.本文报告5例与药物有关的复发性胰腺炎.病例:这些病例均因急性胰腺炎入院,酒精、胆石等病因均可排除,并有明确的服药史,停药后胰腺炎不再复发.讨论:为了确定毒性反应与药物有关,应该在患者完全恢复后重新试用该药进行观察.不过作者认为,胰腺炎是一种严重而有潜在致命危险的疾病,这样做对易感患者来说是不道德的,除非在非常罕见的情况下,为了对另一种严重疾病的持续治疗而非用这种药物不可时.若再次使用该药后,胰腺炎再次发作,而酒精和胆石已排除,即可作为提示因果关系的证据.本组中有4例就是这样,所涉及的药物为扑热息痛、甲灭酸和甲基多巴,在停用有关药物后,迄今未再有胰腺炎发作.甲基多巴和扑热息痛过去已被列为可导致胰腺炎的药物.Vander Heide等报告2例分别在接受甲基多巴2及3周后发病,服250mg后临床及生化都证明有复发.文献中有2例企图服扑热息痛自杀引起急性胰腺炎,但
In addition to alcohol, drug-related acute pancreatitis is rare.This article reports 5 cases of drug-related recurrent pancreatitis.Patients: these cases were hospitalized for acute pancreatitis, alcohol, gallstone and other causes can be ruled out, and there is a clear Medication history, no recurrence of pancreatitis after discontinuation.Discussion: In order to confirm that the toxic reaction is drug-related, the drug should be re-tested after the patient has completely recovered, but the author believes that pancreatitis is a serious and potentially fatal danger , Which is unethical to susceptible patients unless it is not uncommon in the very rare case of continuous treatment of another serious illness other than the use of the drug.If the drug is used again, Pancreatitis attacks again, and alcohol and gallstones have been ruled out, that can be used as a cue to show evidence of causation in this group of 4 cases, the drugs involved are paracetamol, mefenamic acid and methyldopa, the relevant disabled After the drug, so far no further attack of pancreatitis.Midopa and paracetamol in the past has been classified as a drug that can cause pancreatitis.Vander Heide and other reports of 2 patients were receiving methadopa 2 and 3 weeks after the onset of service 250mg Clinical and biochemical relapse are proved. In literature there are two cases of attempted suicide cause acute pancreatitis service paracetamol, but