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目的探讨紫杉醇局部瞬时用药对血管成形术(PTA)后新内膜增生及凝血因子TF表达的影响。材料与方法建立大鼠颈总动脉损伤模型,采取腔内给药,分别在损伤后15、30天观察不同浓度紫杉醇局部瞬时释放对新内膜增生、血管重塑的影响,并通过免疫组织化学染色及原位杂交对损伤后30天血管壁TF的表达进行评估。结果损伤后15天及30天,紫杉醇高浓度(180μg/30μl)2 min、10 min组及低浓度(90μg/30μl)10 min组新生内膜厚度、面积、内膜与中膜面积比及狭窄率等均低于对照组(P<0.05);内、外弹力膜围绕面积与对照组无统计学差异(P>0.05);实验组TF mRNA及TF在新内膜中的表达与对照组没有统计学差别(P>0.05)。结论紫杉醇局部瞬时用药可以在有效持续抑制新内膜增生的同时不增加局部TF的表达。
Objective To investigate the effect of local transient administration of paclitaxel on neointimal hyperplasia and clotting factor TF expression after angioplasty (PTA). Materials and Methods The model of common carotid artery injury in rats was established. After intracavitary administration, the effects of local transient release of paclitaxel at different concentrations on neointimal hyperplasia and vascular remodeling were observed at 15 and 30 days after injury respectively. Immunohistochemistry Staining and in situ hybridization evaluated the expression of TF in the vessel wall 30 days after injury. Results The neointima thickness, area, ratio of intima to media area and stenosis were significantly higher at 15 and 30 days after injury in paclitaxel treated groups (180μg / 30μl for 2 min, 10 min and 90μg / 30μl) (P <0.05). There was no significant difference in the surrounding area between the inner and outer elastic membranes and the control group (P> 0.05). The expression of TF mRNA and TF in the neointima of the experimental group was lower than that of the control group Statistical difference (P> 0.05). Conclusion Paclitaxel local transient administration can effectively inhibit the neointimal hyperplasia without increasing the expression of local TF.