Dubin—Johnson氏综合征是一种少见的先天性非溶血性、非梗阻性、以直接胆红素升高为主的慢性间歇性黄疸,伴有肝细胞内色素沉着。现将我们遇到和搜集的8例报告如下: 一、临床资料:本组患者年龄20～42岁,病程6个月至17年。其中3例有家族史。主要临床表现为黄疸、乏力、食欲下降、恶心、呕吐、右上腹不适及隐痛,少数伴有厌油、失眠、头痛及腹胀。主 Dubin-Johnson’s syndrome is a rare, congenital non-hemolytic, non-obstructive, chronic intermittent jaundice predominated by elevated direct bilirubin accompanied by intrahepatic pigmentation. Now we encountered and collected eight cases are as follows: First, the clinical data: The patients aged 20 to 42 years, duration of 6 months to 17 years. Three of them had a family history. The main clinical manifestations of jaundice, fatigue, loss of appetite, nausea, vomiting, right upper quadrant discomfort and pain, a few with oil-tired, insomnia, headache and bloating. the Lord