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Strebel等对1980～1995年美国的资料分析,认为平均每服用240万剂OPV发生1例VAPP[1]。文献报道中国的服苗者VAPP也偶有发生。特别是随着环境等各方面的变化,免疫缺陷性疾病的种类及发病人数都在上升,且发病前难以对病情进行评估,儿童如此时口服脊灰减毒活疫苗(OPV),就可能出现VAPP的风险。作者于2008年就发现1例,具体情况如下。
Strebel et al. Analyzed data from the United States from 1980 to 1995 and found that 1 case of VAPP occurred on average every 2.4 million doses of OPV [1]. Reported in the literature, VAPP is also occasionally occurred in China. In particular, as the environment and other aspects change, the types of immunodeficiency diseases and the number of patients are on the rise, and it is difficult to assess the condition before the onset of disease. In this case, oral administration of live attenuated poliovirus (OPV) to children may occur VAPP risk. The authors found one in 2008, the details are as follows.