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本实验观察了川芎嗪（TMP）对离体豚鼠心房的作用特点，结果表明：TMP0．1～1mmol／L使右心房自律性和左心房的收缩幅度增高；3mmol／L则使右心房自律性、左、右心房收缩幅度和左心房兴奋性降低，功能不应期略延长。TMP抑制心肌收缩的作用被钾通道阻滞剂四丁胶（1m－mol／L）明显对抗。
The experimental observation of tetramethylpyrazine (TMP) on isolated guinea pig atrial function characteristics of the results showed that: TMP0.1 ~ 1mmol / L to the right atrium self-regulation and left atrial contraction amplitude increased; 3mmol / L is the right atrium self-discipline , Left and right atrial contraction and left atrial excitability decreased, function should not be slightly extended. The effect of TMP on myocardial contractility was significantly antagonized by the tetrabutane (1m-mol / L), a potassium channel blocker.