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目的分析基因修饰小鼠股骨及下颌骨显微CT(microCT)扫描影像的分形维数(FD)。方法采集1-α羟化酶敲除纯合子小鼠(A组)、人成纤维细胞生长因子23过表达小鼠(B组)、1-α羟化酶敲除联合成纤维细胞生长因子23过表达小鼠(C组)和野生型小鼠(D组)的股骨和下颌骨,采用microCT扫描及三维重建影像评估骨质疏松程度,并测量小鼠股骨和下颌骨影像兴趣区域的FD值。结果与D组相比,A、B、C组小鼠股骨和下颌骨的皮质骨厚度、骨小梁容量减少,下颌第一、第二磨牙的牙尖釉质磨耗增加,股骨远端各兴趣区以及下颌第一、第二磨牙牙槽骨的FD值增加(P<0.05);而A、B、C组间股骨和牙槽骨的FD值均无统计学差异(P>0.05)。下颌第一磨牙牙槽骨与股骨远端干骺端的FD值显著相关(r=0.777,P<0.01)。结论 FD值可以较好地反映骨质疏松状况,股骨干骺端和下颌牙槽骨是较合适的兴趣部位,分形分析可运用于下颌骨影像的再分析。
Objective To analyze the fractal dimension (FD) of genetically modified mouse femur and mandibular micro-CT scanning images. Methods 1-α-hydroxylase knockout homozygous mice (group A), human fibroblast growth factor 23 over-expression mice (group B), 1-α hydroxylase knockout combined with fibroblast growth factor 23 The femur and mandible of mice (group C) and wild-type mice (group D) were overexpressed, and the degree of osteoporosis was evaluated by microCT scan and 3D reconstruction images. The FD values of the femur and mandible images were also measured . Results Compared with group D, the thickness of cortical bone and trabecular bone in the femur and mandible of mice in groups A, B and C were decreased, the tooth enamel abrasion of the first and second mandibular molar was increased, (P <0.05). There was no significant difference in FD value between femur and alveolar bone in group A, B and C (P> 0.05). The first molar alveolar bone was significantly associated with the metaphyseal FD value of distal femur (r = 0.777, P <0.01). Conclusion FD value can better reflect the status of osteoporosis. The metaphyseal femoral and alveolar bone of mandible are more suitable sites of interest. Fractal analysis can be applied to the reanalysis of mandible images.